An alkaloid with diverse biological activities; inhibits CYP2D6 and CYP3A4 in vitro (Kis = 54 and 355 μM, respectively); reduces ZIKV NS1 protein expression in HEK293 cells (IC50 = 26.4 nM); reduces viral titer in ZIKV-infected SNB-19 cells (IC50 = 3.11 nM); reduces serum viral load in ZIKV-infected Ifnar1-/- mice at 2 mg/kg; induces emesis in ferrets at 0.5 mg/kg; increases output of respiratory tract fluid in rabbits at 1 mg/kg