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Description
alpha Adaptin Polyclonal Antibody. Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein between the clathrin lattice and the membrane. There are two characterized adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Src homologous and collagen-like (Shc) and epidermal growth factor (EGF) recep
Immunogen
n/a
Other Names
ADTAB, CLAPA2, HIP-9, HIP9, HYPJ, 100 kDa coated vesicle protein C, AP-2 complex subunit alpha-2, adaptin, alpha B, alpha-adaptin C; Huntingtin interacting protein J, alpha2-adaptin, clathrin assembly protein complex 2 alpha-C large chain, clathrin-associated/assembly/adaptor protein, large, al