Purity ~75% (SDS-PAGE). TNIP1 (TNFAIP3-interacting protein 1) has been shown to interacts with zinc finger protein A20/TNFAIP3 and inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal. In addition, interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. It may regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. Source: Recombinant corresponding to aa94-530 of human TNIP1 protein, fused to His-tag at N-terminus, expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MSNVTASPTA PACPSDKPAP VQKPPSSGTS SEFEVVTPEE QNSPESSSHA NAMALGPLPR EDGNLMLHLQ RLETTLSVCA EEPDHGQLFT HLGRMALEFN RLASKVHKNE QRTSILQTLC EQLRKENEAL KAKLDKGLEQ RDQAAERLRE ENLELKKLLM SNGNKEGASG RPGSPKMEGT GKKAVAGQQQ ASVTAGKVPE VVALGAAEKK VKMLEQQRSE LLEVNKQWDQ HFRSMKQQYE QKITELRQKL ADLQK
Size
10ug
Concentration
n/a
Applications
n/a
Other Names
ABIN-1, Recombinant, Human (TNIP1, TNFAIP3 Interacting Protein 1, HIV-1 Nef-interacting Protein, Nef-associated Factor 1, Naf1, Nip40-1, Virion-associated Nuclear Shuttling Protein, VAN, hVAN, KIAA0113, NAF1)