Purified (~75%). The c-ABL proto-oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c-ABL proto- oncogene undergoes a chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) as a result of the fustion of c-ABL sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/ABL mRNA encoding activated ABL protein tyrosine kinase. Source: Recombinant corresponding to aa248-531 from human Abelson murine leukemia viral oncogene homolog 1, with T334I mutation, fused to His-tag at N-terminal, expressed in a Baculovirus-infected Sf9 cell expression system. Molecular Weight: ~33kD Applications: Suitable for use in the study of enzyme kinetics, screening inhibitors, and selectivity profiling.