MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
Size
Various Sizes
Concentration
n/a
Applications
Cell Culture
Other Names
C-C motif chemokine 22;Activated B and dendritic cell-derived;CC chemokine ABCD-1;Small-inducible cytokine A22;Ccl22;Abcd1, Scya22; Macrophage-Derived Chemokine, CCL22, STCP-1, ABCD-1