Purity ~90% (SDS-PAGE). Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. Source: Recombinant protein corresponding to aa1-471 from human MLKL, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~70.5kD AA