A natural sesquiterpene with diverse biological activity; lethal against ticks, fleas, and mosquitoes (LC50s = 0.0029, 0.0061, and 0.0046% w/v, respectively); reduces tunnel lengths, feeding, and survival rates in C. formosanus termites; dose-dependently activates AMPKα1 and AMPKα2 in C2C12 mouse myoblast lysate containing a substrate peptide from 10-100 μM; inhibits platelet aggregation induced by collagen, thrombin, and arachidonic acid from 10-100 μM; dose-dependently increases the length of tail bleeding time in mice from 3-30 mg/kg; reduces body weight and plasma glucose levels in mice fed a high-fat and high-sucrose diet ,