LRIG3, Recombinant, Human (Leucine-rich Repeats and Ig-like domains-3, LIG-3)
Description
Purity ≥ 95% as determined by SDS-PAGE and visualized by silver stain. LRIG3 (leucine-rich repeats and Ig-like domains-3) is a 140 kD type I transmembrane glycoprotein member of the mammalian LRIG glycoprotein family. This family contains three members who share 45-50% amino acid (aa) identity. 1 All members contain at least fifteen LRRs, accompanied by two flanking cysteine-rich regions, and three C2-type Ig-like domains in their extracellular domains (ECD). 1 LRIG3 mRNA is widely expressed, with highest levels in stomach, skin, thyroid and small intestine. 1 Human LRIG3 is synthesized as an 1120 amino acid (aa) precursor. It contains a 24 aa signal sequence, a 786 aa ECD, a 21 aa transmembrane sequence, and a 289 aa intracellular region. One splice variant exists that has a 19 aa substitution for the first 79 aa of the standard (or long) form. This substitution appears to encode an alternate signal sequence, resulting in a mature protein that lacks the first and part of the second LR