HVEM belongs to the TNF Receptor superfamily of transmembrane proteins and plays a role in the activation of T-cells and other lymphocytes. It is expressed in various cells and tissues including spleen, thymus, lung, macrophages, and T-cells. HVEM activation induces a signaling cascade which results in induction of transcription factors NF-kappaB and AP-1. LIGHT (TNFSF14) and TNF-β (TNFSF1) function as the ligands for HVEM, which can also bind specifically to herpes simplex virus glycoprotein D. Soluble HVEM can act as a ``receptor decoy'' resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-β. Recombinant human HVEM-Fc Chimera is a 376 amino acid fusion protein containing an N-terminal domain corresponding to the extracellular region of HVEM and a C-terminal domain corresponding to residues 102 to 330 of human IgG1.
Size
Various Sizes
Concentration
n/a
Applications
Cell Culture
Other Names
Immunoglobulin heavy constant gamma 1 ;Ig gamma-1 chain C region ;Ig gamma-1 chain C region EU ;Ig gamma-1 chain C region KOL ;Ig gamma-1 chain C region NIE ;IGHG1 ; HVEM, TNFSFR14, ATAR, TR2