Purity >90% (SDS-PAGE). SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Sequence: Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG1.
Size
10ug
Concentration
n/a
Applications
n/a
Other Names
SIGIRR,Fc, Recombinant, Human (Toll/Interleukin-1 Receptor 8, TIR8, Single Ig IL-1R-related Molecule)