Purity ~90% (SDS-PAGE). Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its Extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity). Source: Recombinant protein corresponding to aa1-117 from mouse Sigirr, fused to His-Tag at N-terminal, expressed in Yeast. Molecular Weight: ~14.7kD AA
Size
10ug, 50ug, 100ug
Concentration
n/a
Applications
n/a
Other Names
Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein, Toll/interleukin-1 receptor 8, TIR8