Purity ~90% (SDS-PAGE). Controlled and limited pepsin digestion, followed by selective salt precipitation. Collagens are highly conserved throughout evolution and are characterised by an uninterrupted Glycine X Y triplet repeat that is a necessary part of the triple helical structure. Type I collagen (95kD) is found in bone, cornea, skin and tendon. Mutations in the encoding gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for Platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Source: Placental villi Applications: Suitable for use as Type VI collagen standard, antigen for antibody production, coating material for cell culture studies, and formation of collagen gels.