Collapsin Response Mediator Protein 1, CT, Control Peptide
Description
Synthetic peptide CRMP1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human CRMP1 (Genbank accession No. AAH07613). Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons and to participate in axonal specification. The X-ray crystal structure of murine CRMP1 was determined at 2.1 resolution and demonstrates that CRMP1 is a bilobed 'lung-shaped' protein forming a tetrameric assembly. Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity. CRMP-1 was initially identified as a
Size
50ug
Concentration
n/a
Applications
WB
Other Names
Collapsin Response Mediator Protein 1, CT, Control Peptide (CRMP1, Dihydropyrimidinase-like 1, DPYSL1, DRP1, ULIP3, CRAM)