Collectrin, Fc Chimera, Recombinant, Human, aa15-141 (NX17, TMEM27)
Description
Purity ~95% (SDS-PAGE). Collectrin, also known as TMEM27 and NX-17, is a 35-45kD transmembrane protein that shows structural similarity to the C-terminal region of Angiotensin Converting Enzyme 2 (ACE-2) but lacks peptidase activity (1, 2). Mature human Collectrin consists of a 127 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 60aa cytoplasmic domain (3). Within the ECD, human Collectrin shares 87% and 89% aa sequence identity with mouse and rat Collectrin, respectively. Collectrin is expressed as a disulfide-linked homodimer of variably glycosylated subunits (4-6). It is highly expressed in the proximal convoluted tubules of renal collecting ducts and inhibits the proliferation of tubule epithelial cells (3, 6-8). It associates with several amino acid transporters on the luminal surface of these cells, where it is required for the reabsorption of multiple amino acids (7-9). Collectrin is also expressed in pancreatic islet beta cells and enhances gluc