Collectin 11, Recombinant, Mouse (Collectin Kidney Protein 1, CL-K1, COLEC11)
Description
Purity ≥85%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain. 33-38kD Endotoxin: ≤1EU per 1ug of protein (LAL). Collectins constitute a family of C-type lectins that recognize molecular patterns expressed on pathogens. Members of this glycoprotein family contain a N-terminal domain, a collagen-like domain, a neck region, and a C-terminal carbohydrate recognition domain (CRD). Collectins are typically secreted molecules, although CL-P1 is membrane bound and CL-L1 is found in the cytoplasm. Collectin kidney 1 (CL-K1), also known as collectin subfamily member 11 (COLEC11), is a 37kD collectin that circulates in the serum. It associates into disulfide-linked oligomers and preferentially interacts with fucose residues in a calcium-dependent manner. Mature mouse CL-K1 shares 94% and 98% amino acid sequence identity with human and rat CL-K1, respectively. Within the CRD, mouse CL-K1 shares 52% aa sequence identity with CL-L1 and 23%-32% aa sequence identity