EPHA1, Recombinant, Human, aa613-892, GST-Tag (Ephrin Type A Receptor 1, EPH, EPHT, EPHT1)
Description
Purified (~70-90%). EPHA1 is a member of the Eph family of receptor tyrosine kinases that have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the Eph subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. EPHA1 seems to be a marker of the differentiated normal epidermis an its downregulation in nonmelanoma skin cancer may contribute to carcinogenesis of these very frequent human tumors. EPHA1 represents a new potential prognostic marker and therapeutic target in nonmelanoma skin cancer. Source: Recombinant protein corresponding to aa613-892 from human EPHA1, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~55kD Specific Activity: 20nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL)