Purity ~90% (SDS-PAGE). EPHB2, also known as ephrin type-B receptor 2 isoform 1, is a member of the transmembrane Eph receptor tyrosine kinase family (RTKs) that binds members of the Ephrin family on adjacent cells. The interaction triggers forward signaling in the receptor-expressing cells through the Eph receptor and reverse signaling in the ligand-expressing cells through Ephrin. Hippocampal neurons can release vesicles containing full length EPHB2, and these are taken up by neighboring glial cells. This protein controls axon guidance across the embryonic midline, promotes a neuronal fate from neural precursors, and regulates NMDA receptor activity. Source: Recombinant protein corresponding to aa19-543 from human EPHB2, fused to His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~59.1kD (533aa), 50-70kD (SDS-PAGE under reducing conditions.) Endotoxin: <1EU/1ug (determined by LAL method) AA