Purity ~90% (SDS-PAGE). Type IV collagen is the major structural component of glomerular basent membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin. Source: Recombinant protein corresponding to aa1445-1669 from human COL4A1, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~40.9kD AA