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Description
Keratin K5 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. The type II cytokeratin genes are clustered in a region of chromosome 12q12-q13. Keratin K8 is specifically expressed in the basal layer of the epidermis with family member KRT14. Antibodies to CK8 can be used to differentiate lobular carcinoma of the breast from ductal carcinoma of the breast. Keratin 8 is often used together with keratin 18 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.
Immunogen
Keratin K5/K8 Pan Epithelial antibody was raised in mouse using Lung cancer cell preparation as the immunogen.
Other Names
Keratin K5/K8 Pan Epithelial , Keratin K5/K8 Pan Epithelial , Cytokeratin 5/8 pan epithelial .