A polyphenolic phytoalexin found in a variety of plants; has anti-inflammatory, antioxidant, and anticancer activities; inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively), but not COX-2 (EC50s = >100 μM and 85 μM, respectively); inhibits carrageenan-induced paw edema in mice at 3 and 8 mg/kg; inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by TPA (EC50 = 27 μM); reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and DMBA at 1-25 μmol; activates SIRT1 by 8-fold in vitro at 200 μM; inhibits ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, in vitro and/or ex vivo; prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice