Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) (N-Term), (pSer516)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
human
Isotype
n/a
Format
unconjugated
Size
0.1 mg
Concentration
n/a
Applications
n/a
Reviews / Ratings
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Description
HRX (Histone-lysine N-methyltransferase HRX) functions as histone methyltransferase. HRX methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. HRX promotes PPP1R15A-induced apoptosis. HRX interacts with SBF1 and PPP1R15A. HRX is a component of the MLL complex, at least composed of MLL, ASH2L, RBBP5, DPY30, WDR5, MEN1,HCFC1 and HCFC2. Chromosomal aberrations involving MLL are a cause of acute leukemias. A chromosomal aberration involving MLL may be a cause of chronic neutrophilic leukemia. HRX belongs to the histone-lysine methyltransferase family and TRX/MLL subfamily.Synonyms: ALL1, CXXC7(CXXC-type zinc finger protein 7), HTRX, KMT2A, TRX1, MLL, Zinc finger protein HRX, Trithorax-like protein, Lysine N-methyltransferase 2A
Immunogen
Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to near N-terminal residues of human HRX (Histone-lysine N-methyltransferase HRX)