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Description
There are four member of the KChiPs (Kv4 potassium channel interacting protein) family. They are all EF hand containing proteins required for the traffic of channel forming Kv4 K+ subunits to the plasma membrane. KChiP2 expression has been found to be significantly decreased in hypertrophy and heart failure, and does so thru modulatin of intracellular concentration and calcineurin/NFAT pathways. It has also been found that KChiP2 also functionally modulates the Cav1.2 governed Ltype calcium channel through a direct interaction between KChiP2 and the amino-terminus of Cav1.2.Cellular Localization: Cell Membrane
Immunogen
Fusion protein amino acids 1-252 (Full length) of rat KChIP2b