Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1)
Clone
7A2
Host Species
Mouse
Reactive Species
human, mouse, monkey
Isotype
IgG1
Format
ascites
Size
100 μL
Concentration
n/a
Applications
ELISA,Western Blotting (WB)
Reviews / Ratings
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Description
E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.
Immunogen
Purified recombinant fragment of human CDH1 expressed in E. coli.