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Description
Complement component C9 is a multi-domain protein that contains an N-terminal type-1 TSP domain, an LDL-receptor class A repeat, a number of potential transmembrane regions and a C-terminal EGF-like domain. Hydropathy analysis of the sequence indicates the N-terminal half of C9 to be predominantly hydrophilic in character, while the C-terminal section is more hydrophobic. The amphipathic organisation of the primary structure is consistent with the known potential of polymerised C9 to penetrate lipid bilayers, causing the formation of transmembrane channels.
Immunogen
Human Complement C9Sheep serum was obtained from healthy animals of UK origin and under the care of a registered veterinarian.