A macrocyclic trichothecene mycotoxin that has been found in M. verrucaria; inhibits FGFR3, IGF-1R, PDGFRβ, and TrkB (IC50s = 0.4, 0.4, 1.4, and 1 μM, respectively); induces cytotoxicity in multiple breast cancer cell lines (IC50s = 0.02-0.05 nM); inhibits proliferation in a panel of additional cancer cell lines (IC50s = 50s = 1.74-7.68 nM); inhibits the growth of P. falciparum (EC50 = 0.15 ng/ml); induces phytotoxicity in duckweed and kudzu; toxic to mice (LD50 = 10 mg/kg, i.p.); also produced by the plant B. coridifiola, which is associated with livestock poisoning in South America