Purity > 90% as determined by SDS-PAGE. MW: 52kDa. Full Length of Mature Protein: 26-349aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.