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Description
Caspase 9 Polyclonal Antibody, HRP Conjugated. ? Target Background: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
Immunogen
KLH conjugated synthetic peptide derived from human Caspase 9 subunit p35. Immunogen Range: 20-69/416