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Description
Polyclonal antibody to detect endogenous levels of MEF2A in human, mouse and rat. Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MEF2A
Other Names
MEF2; Myocyte-specific enhancer factor 2A; Serum response factor-like protein 1