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Description
Function: Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.Catalytic activity: ATP + a protein = ADP + a phosphoprotein.Subcellular location: Cytoplasm. Nucleus. Note: Isoform LIMK2a is distributed in the cytoplasm and the nucleus, and isoform LIMK2b occurs mainly in the cytoplasm and is scarcely translocated to the nucleus.Tissue specificity: Highest expression in the placenta, moderate level in liver, lung, kidney, and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and placenta LIMK2b is the dominant form. In adult lung, both LIMK2a and LIMK2b is nearly equally observed. Also known as: LIM domain kinase 2, LIMK-2.
Immunogen
A synthetic peptide from the phospho S291 & S293 region of human LIMK2 (LIM domain kinase 2, LIMK-2) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat, mouse.