Recombinant Human Ras GTPase-activating protein SynGAP (SYNGAP1), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 25.5kDa. Partial: 1161-1343aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.