Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:2000
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Description
FAF1 Monoclonal Antibody (OTI2F9). Fas-associated protein 1 (FAF1) was initially identified as a Fas-binding pro-apoptotic protein that is component of the death-inducing signaling complex in Fas-mediated apoptosis. FAF1 can also induce apoptosis in the absence of extrinsic death signals when overexpressed although it does not contain typical death motifs such as the death domain, death effector domain, and caspase recruitment domain. Overexpression of FAF1 also decreases the basal level of NF-kappa-B activity in transfected 293 cells, inhibits NF-kappa-B activity induced by TNF-a, IL-1-b and lipopolysaccharide, and prevents NF-kappa-B translocation to the nucleus, suggesting that another role of FAF1 is to negatively regulate the activity
Immunogen
n/a
Other Names
HFAF1s, UBXD12, UBXN3A, hFAF1, FAS-associated factor 1, TNFRSF6-associated factor 1, UBX domain protein 3A, UBX domain-containing protein 12, UBX domain-containing protein 3A