A dual SPHK1 and SPHK2 inhibitor (Kis = 0.73 and 0.9 μM, respectively, using human recombinant kinases); selective for Sphk2 over Sphk1 in mice (Kis = 1 and 20 μM, respectively); not selective in rat (Kis = 1.1 and 0.8 μM for Sphk2 and Sphk1, respectively); decreases S1P in vitro at concentrations of 0.1 and 0.3 μM; decreases S1P in Sphk1-/- knockout mice and in rat at a dose of 10 mg/kg