Purity ~95% (SDS-PAGE). Endotoxin Level: ≤1.0 EU/1ug (LAL). LMIR3, also known as CD300LF, CD300F, IREM-1, CLM-1, IgSF13, DIgR1, and MAIR-V, is a 50-60kD glycoprotein member of the immunoglobulin superfamily. Human LMIR3 consists of a 137aa extracellular domain (ECD) with one Ig-like V-type domain, a 21aa transmembrane segment, and a 113aa cytoplasmic domain that contains multiple immunoreceptor tyrosine-based inhibitory motifs (ITIMs) or ITIM-like sequences. Alternate splicing generates additional isoforms that carry substituted C-terminal tails of varying lengths and sequences following the ECD or transmembrane segment. Within the ECD, human LMIR3 shares 43? sequence identity with mouse and rat LMIR3. LMIR3 is expressed on the surface of dendritic cells, monocytes, granulocytes, and mast cells as well as on acute myeloid leukemia (AML) blasts. Pervanadate treatment or antibody cross-linking of LMIR3 induces phosphorylation of tyrosine residues in the cytoplasmic domain and the subsequ
Size
50ug
Concentration
n/a
Applications
n/a
Other Names
LMIR3, Recombinant, Human (CMRF35-like Molecule 1, CLM-1, CD300 Antigen-like Family Member F, Immune Receptor Expressed on Myeloid Cells 1, IREM-1, Immunoglobulin Superfamily Member 13, IgSF13, CD300f, NK Inhibitory Receptor, CD300LF, CD300F, CLM1, IGSF13, IREM1, NKIR, UNQ3105/PRO10111)