RASSF5, Recombinant, Human, aa1-265, GST-Tag (Ras Association Domain-containing Protein 5)
Description
Purity ~90% (SDS-PAGE). Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. Source: Recombinant protein corresponding to aa1-265 from human RASSF5, fused to GST-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~57.4kD AA
Size
10ug, 50ug, 100ug
Concentration
n/a
Applications
n/a
Other Names
New ras effector 1 Regulator for cell adhesion and polarization enriched in lymphoid tissues