Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:1000
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Description
DUSP14 Polyclonal Antibody. DUSP14 is involved in the inactivation of MAP kinases. This proein dephosphorylates ERK, JNK and p38 MAP-kinases. In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28, which interacts with B7-1 (CD80) and B7-2 (CD86) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK and JNK, and the subsequent creation of AP1 transcription factor. DUSP14 is a negative regulator of CD28 signaling.
Immunogen
n/a
Other Names
Mitogen-activated protein kinase phosphatase 6; MAP kinase phosphatase 6; MKP-6; MKP-1-like protein tyrosine phosphatase; MKP-L;