Protein Arginine Methyltransferase 1 (PRMT1) protein (His tag,MBP tag)
Description
PRMT1 Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (may methylate HNRNPA1 and histones). Methylates SUPT5H.The PRMT1 protein functions as a histone methyltransferase specific for H4.PRMT1 is an essential factor in oncogenesis and is a potential novel therapeutic target in cancer.PRMT1-mediated methylation serves as a positive modulator of IR/IRS-1/PI3K pathway and glucose uptake in skeletal muscle cells. CAF1 is a new regulator of PRMT1-dependent arginine methylation.PRMT1 arginine-methylates MRE11 therefore it regulates the activity of MRE11-RAD50-NBS1 complex during the intra-S-phase DNA damage checkpoint response.PRMT1 plays a post-translationally part in regulating the transcriptional activity.PRMT1is found predominantly in the cytoplasma though a fraction of PRMT1 is located in the nucleus Synonyms: ANM1, HCP1, HRMT1L2, IR1B4, Interferon receptor 1-bound protein 4, EC 2.1.1, Protein arginine N-methyltransferase 1, Prmt1, AW214366, 6720434D09Rik
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
ARABIDOPSIS THALIANA PROTEIN ARGININE METHYLTRANSFERASE 1A|ATPRMT1A|F6F22.30|F6F22_30|protein arginine methyltransferase 1A|prmt1|DDBDRAFT_0183976|DDBDRAFT_0235399|DDB_0183976|DDB_0235399|PRMT1|DKFZp459J1326|ANM1|HCP1|HRMT1L2|IR1B4|fb39h07|hrmt1l2|wu:fb39h07|zf1|zgc:66201|3E10|Hrmt1l2|anm1|hcp1|ir1b4|xPRMT1|xPRMT1b|6720434D09Rik|AW214366|Mrmt1