HtrA2/Omi(S306A), 134-458 aa, Human, His tag, E.coli
Description
Purity: > 95% by SDS - PAGE Format: Liquid. In 20 mM Tris-HCl buffer (pH 8.0), 50 mM NaCl, 1 mM DTT, 20% Glycerol. HtrA2/Omi is a mammalian serine protease at high temperatures and has a chaperone activity at low temperature. The full-length HtrA2 is synthesized as a precursor protein and then targeted to the mitochondria where it is matured by the removal of N-terminal 133 residues. Mature HtrA2 consists of a putative transmembrane domain; an inhibitor of apoptosis protein (IAP)-binding motif; a single C-terminal PDZ domain that mediates protein-protein interactions. Recently, HtrA2 has known to contribute both to caspase-dependent and caspase-independent cell death. Mature form of HtrA2/Omi(residues 134-458) was overexpressed in E.coli, and purified by conventional column chromatography techniques.
Size
0.5mg, 100ug, 20ug
Concentration
n/a
Applications
SDS-PAGE
Other Names
High temperature requirement protein A2, HTRA2, OMI, PRSS25, HtrA2/Omi, EC 3.4.21.108, High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine proteinase OMI, Serine protease 25, Serine protease HTRA2, mitochondrial, High temperature requirement protein A2