Recombinant Human Sperm-egg fusion protein Juno (IZUMO1R)
Description
Purity > 90% as determined by SDS-PAGE. MW: 30.3kDa. Full Length of Mature Protein: 20-250aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate (By similarity).