Immunohistochemistry: 1:50-1:100, Western Blot: 1:1000
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Description
ACVR2B Polyclonal Antibody. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form
Immunogen
n/a
Other Names
Activin receptor type 2B [Precursor]; Activin receptor type IIB; ACTR-IIB; ACVR2B;