Immunoprecipitation: 2-5 μg/mg lysate, Western Blot: 1:500-1:5,000
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Description
Roquin Polyclonal Antibody. The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.
Immunogen
n/a
Other Names
RC3H1, Ring finger and CCCH-type domains 1, ring finger protein 198, RNF198, roquin