An inhibitor of USP14 and UCHL5, two proteasome-associated deubiquitinases; inhibits DUB activity in purified 19S proteasomes with an IC50 value of 2.1 μM; blocks tumor progression in vivo in mice and prevents organ infiltration in mouse models of myeloid leukemia
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
330450-45-8 inhibitors cancers ubiquitin proteasomes deubiquitinases USPs UCHLs USP-14 USP14 14 UCHL-5 UCHL5 proteasome-associated DUBs b AP15 bAP15 ubiquitin-specific-processing protease 14 specific processing process carboxyl-terminal hydrolase isozyme L5 carboxyl terminal in vivo tumor cells T cells apoptosis TNF IV