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Description
Function: May be involved in regulating membrane traffic to and from trans-Golgi network.Subcellular location: Cell membrane, Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane, Single-pass type I membrane protein. Note: Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes.Tissue specificity: Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells.Miscellaneous: Not found in strains BALB/c, C57BL/6 and DBA/2. Also known as: Trans-Golgi network protein TGN51, TGN46, TGN48, TGN38 homolog, Trans-Golgi network integral membrane protein 2, TGOLN2.
Immunogen
A synthetic peptide from aa region 310-360 of mouse TGN38 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and human.