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Description
Rat Anti-Lrp6 Recombinant Antibody (290913). Provided herein is a Rat monoclonal antibody, which binds to Low Density Lipoprotein Receptor-Related Protein 6 (Lrp6). The antibody can be used for immunoassay techniques, such as WB. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a essential role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylati
Immunogen
Chinese hamster ovary cell line CHO-derived recombinant mouse LRP-6, Met1-Pro1368, Accession # O88572.
Other Names
Cd; Gw; ska26; skax26; ska; C030016K15Rik; low-density lipoprotein receptor-related protein 6; LRP-6; crooked; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; low density lipoprotein-related protein 6