Recombinant Human Ubiquitin carboxyl-terminal hydrolase 14 (USP14)
Description
Purity > 90% as determined by SDS-PAGE. MW: 60.1kDa. Full Length: 1-494aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chokine receptor CXCR4 which is critical for CXCL12-induced cell chotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).