An aminopeptidase inhibitor (IC50s = 100, 150, and 220 nM for LAP, PUSA, and aminopeptidase N, respectively); inhibits proliferation of human leukemia cell lines in vitro irrespective of p53, PTEN, or K-RAS mutational status (IC50s = 10-770 nM); induces up-regulation of genes in amino acid transport and metabolic pathways and inhibits phosphorylation of mTOR substrates in HL-60 cells; reduces total tumor burden and the number of spontaneous metastases in a mouse MDA-MB-435 xenograft model when administered at a dose of 100 mg/kg