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Description
IGF1R (Tyr1161) Polyclonal Antibody, Biotin Conjugated. ? Target Background: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq,
Immunogen
KLH conjugated synthetic phosphopeptide derived from human IGF1R around the phosphorylation site of Tyr1161. Immunogen Range: 1130-1180/1367