Purity > 90% as determined by SDS-PAGE. MW: 55.7kDa. Full Length of Mature Protein: 33-380aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Periodontal ligament-associated protein 1; Short name:PLAP-1