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Description
RCAN1 Monoclonal Antibody (4D9-G3). The RCAN1 protein interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. This antibody is specific for Isoform RCAN1-1L, which is overexpressed in Alzheimer's Disease (Harris, C.D. et al) and is downregulated in Huntington's Disease (Ermak, G. et al). The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the
Immunogen
n/a
Other Names
ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1, Down syndrome candidate region 1, Down syndrome critical region gene 1, calcipressin-1, calcium and oxidant-inducible mRNA, down syndrome critical region protein 1, modulatory calcineurin-interacting protein 1, myocyte-enriched calcineurin-interacting protein 1, near DSCR proline-rich protein