產(chǎn)品名稱 LX-2343 from BIOVISION, INC.
    產(chǎn)品貨號(hào) B2120-5
    產(chǎn)品價(jià)格 現(xiàn)貨詢價(jià)，電話：010-67529703
    產(chǎn)品規(guī)格 5 mg
    產(chǎn)品品牌 BIOVISION, INC.
    產(chǎn)品概述
    產(chǎn)品詳情
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    Product NameLX-2343
    DescriptionLX-2343 is a neuroprotective agent for the treatment of Alzheimer's disease. LX2343 ameliorates cognitive dysfunction in APP/PS1 transgenic mice via both Aβ production inhibition and clearance promotion. LX2-343 dose-dependently decreases Aβ accumulation in HEK293-APPsw and CHO-APP cells,and promotes Aβ clearance in SH-SY5Y cells and primary astrocytes. The anti-amyloid effects of LX2343 are attributed to suppressing JNK-mediated APPThr668 phosphorylation, thus inhibiting APP cleavage on one hand, and inhibiting BACE1 enzymatic activity with an IC50 value of 11.43±0.36 μmol/L, on the other hand. MW: 474.91. Purity ≥98% by HPLC
    Size5 mg
    Concentrationn/a
    Applicationsn/a
    Other NamesN-(benzo[d][1,3]dioxol-5-yl)-2-(N-(5-chloro-2-methoxyphenyl)phenylsulfonamido)acetamide
    Gene, Accession, CAS #CAS: 333745-53-2
    Catalog #B2120-5
    Price
    Order / More InfoLX-2343 from BIOVISION, INC.
    Product Specific Referencesn/a
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