A potent inhibitor of LIMK1, LIMK2, ROCK-1, and ROCK-2 kinases (IC50s = 32, 4.3, 69, and 32 nM, respectively); selective, showing no cross reactivity in a panel of binding assays including 78 receptors, at a concentration of 10 μM; topical administration (3 μl of 1 mg/ml solution) to the eye reduces intraocular pressure in a dexamethasone-induced mouse model of glaucoma,